The phrase "great despair" means feeling extremely sad or hopeless.
Sentences with «great despair»
Today, I am a 21 - year - old college graduate and am writing this with great despair — and even more anger. (sun-sentinel.com)
Many of us end up in great despair when we can not sell. (remonline.com)
But Jesus» use of the words expresses a much greater despair at the isolation that he was experiencing as he, God the Son, was alienated from God, his own Father. (premierchristianity.com)